HUNK

Across TCGA cell cohorts, HUNK mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HUNK-associated genes across cancer lineages are CEACAM3, KRT71, and TAS2R60. Each is linked with HUNK in more than 1 cancer types. Because this analysis shows association rather than direction, both HUNK-to-partner and partner-to-HUNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by HUNK-low versus HUNK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUNK→partner) and Y-score (partner→HUNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEACAM3 →	+0.509	+2.710	<.001	.004	3	2
SKIN	KRT71 →	+0.049	+4.977	<.001	.007	3	1
LUNG_SCLC	TAS2R60 →	+1.253	+5.643	<.001	.002	3	1
BLOOD_Leukemia	TP53TG3E →	+0.023	+3.874	.003	.005	3	1
OVARY	METTL21C →	+0.049	+3.791	<.001	.007	3	1
OVARY	LCN9 →	+0.020	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

CEACAM3 by HUNK expression — LARGE_INTESTINE

Explore this box plot interactively →