Across TCGA pan-cancer cohorts, HTT mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HTT data layer compared with 19 for mass-spec protein and 8 for mutation status.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HTT expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.
UCEC, LSCC, and COAD are the cancer types where HTT mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.