Across TCGA patient cohorts, HTT RNA expression is significantly associated with the protein abundance of many other proteins, with 9,001 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HTT-associated proteins across cancer lineages are BOD1L1, CTBP1, and RGS12. Each is linked with HTT in more than 3 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BOD1L1 →	+0.208	+0.434	<.001	<.001	3	4
PDAC	CTBP1 →	+0.315	+0.296	<.001	<.001	3	4
LSCC	RGS12 →	+0.372	+0.512	<.001	<.001	3	4
BRCA	ARFGAP3 →	-0.301	-0.466	.002	.009	3	3
LSCC	NELFA →	+0.257	+0.442	<.001	<.001	3	3
LSCC	NSD2 →	+0.305	+0.324	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,001 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types