Across TCGA patient cohorts, HTT mutation is significantly associated with the RNA expression of many other genes, with 5,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTT-associated genes across cancer lineages are TUBGCP5, PTMAP4, and ACBD5. Each is linked with HTT in more than 4 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP5 →	+0.298	+1.416	<.001	<.001	3	4
COAD	PTMAP4 →	+0.938	+1.847	<.001	.006	3	4
UCEC	ACBD5 →	+0.347	+1.196	.001	.003	3	4
STAD	CCNB1 →	+0.694	+2.700	.006	.006	3	4
UCEC	MRPL44 →	+0.357	+1.534	<.001	<.001	3	4
UCEC	NDUFAF1 →	+0.359	+1.625	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,766 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types