Across TCGA patient cohorts, HTT mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTT-associated genes across cancer lineages are Smad4, PCNA, and Caspase-7-cleavedD198. Each is linked with HTT in more than 2 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Smad4 →	+0.148	+3.000	.016	.034	3	3
UCEC	PCNA →	+0.229	+2.169	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.391	+1.189	.007	.009	3	3
UCEC	4E-BP1 →	+0.268	+1.415	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.095	-2.246	<.001	<.001	3	2
UCEC	eEF2 →	+0.289	+1.938	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types