Across TCGA cell cohorts, HTT mutation is significantly associated with the RNA expression of many other genes, with 649 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTT-associated genes across cancer lineages are SULT2A1, KIAA1328, and SKA1. Each is linked with HTT in more than 2 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SULT2A1 →	+0.041	+2.321	<.001	.009	3	3
LARGE_INTESTINE	KIAA1328 →	+0.478	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	SKA1 →	+0.857	+2.364	<.001	<.001	3	3
LUNG_SCLC	TECTB →	+0.042	+2.616	.006	.005	3	2
CNS	HELT →	+0.023	+3.099	<.001	.004	3	2
BREAST	OR10K2 →	+0.031	+3.781	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 649 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types