Across TCGA cell cohorts, HTT mutation is significantly associated with the mutation status of many other genes, with 4,497 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTT-associated genes across cancer lineages are FAT4, MACF1, and RYR1. Each is linked with HTT in more than 6 cancer types. Because this analysis shows association rather than direction, both HTT-to-partner and partner-to-HTT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTT→partner) and Y-score (partner→HTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAT4 →	+2.616	+2.616	.007	.007	1	7
SOFT_TISSUE	MACF1 →	+2.608	+2.882	<.001	<.001	1	7
LARGE_INTESTINE	RYR1 →	+1.788	+2.411	<.001	<.001	1	7
BLOOD_Leukemia	ZBED1 →	+4.686	+2.700	<.001	<.001	1	6
CNS	DNHD1 →	+3.201	+3.491	<.001	<.001	1	6
BLOOD_Leukemia	EPHB6 →	+3.016	+2.833	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,497 associations by consensus.

Exploration

HTT survival (RNA) · tumor vs normal (RNA) · all HTT data types