HTRA2

Across TCGA pan-cancer cohorts, HTRA2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HTRA2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HTRA2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HTRA2 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where HTRA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.886	.024	24	view →
CCRCC	OS	Tertile	All	0.965	0.776	.013	17	view →
PDAC	DFS	Quartile	All	0.660	0.959	.006	9	view →
OV	DFS	Median	All	0.970	0.587	.021	4	view →
LUAD	OS	Quartile	All	0.872	0.671	.020	4	view →
UCEC	OS	Median	All	0.857	0.966	.036	2	view →
LSCC	DFS	Tertile	All	0.666	1.000	.018	2	view →
GBM	DFS	Quartile	All	0.818	0.563	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HTRA2–COAD (DFS)

Open the COAD breakdown →