HTRA2

Across TCGA patient cohorts, HTRA2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTRA2-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and A-Raf_pS299. Each is linked with HTRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA2-to-partner and partner-to-HTRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by HTRA2-low versus HTRA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA2→partner) and Y-score (partner→HTRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.176	+2.000	.002	.030	3	2
UCEC	EGFR_pY1068 →	-0.229	-1.807	.027	.027	3	1
UCEC	A-Raf_pS299 →	-0.134	-1.807	.006	.027	3	1
UCEC	Gab2 →	+0.351	+2.321	.017	.034	3	1
UCEC	JNK2 →	+0.205	+2.834	.012	.034	3	1
UCEC	MEK1 →	+0.375	+3.459	.012	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

C-Raf by HTRA2 expression — UCEC

Explore this box plot interactively →