HTRA2

Across TCGA cell cohorts, HTRA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,751 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTRA2-associated GO terms across cancer lineages are Mitochondrial protein catabolic process, Maintenance of blood-brain barrier, and Mitochondrial tRNA processing. Each is linked with HTRA2 in more than 11 cancer types. Because this analysis shows association rather than direction, both HTRA2-to-partner and partner-to-HTRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial protein catabolic process grouped by HTRA2-low versus HTRA2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA2→partner) and Y-score (partner→HTRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mitochondrial protein catabolic process →	+0.187	+0.744	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	-0.216	-0.823	.001	<.001	3	8
CNS	Mitochondrial tRNA processing →	+0.072	+0.460	.002	.001	3	8
SKIN	Protein-RNA covalent cross-linking repair →	+0.097	+0.540	<.001	.001	2	9
LARGE_INTESTINE	Positive regulation of mitotic cell cycle phase transition →	+0.060	+0.483	<.001	.001	3	8
PANCREAS	Mitochondrial RNA modification →	+0.057	+0.433	.005	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,751 associations by consensus.

Mitochondrial protein catabolic process by HTRA2 expression — LARGE_INTESTINE

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