HTRA2

Across TCGA cell cohorts, HTRA2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTRA2-associated genes across cancer lineages are C5orf52, TSSK1B, and SMIM31. Each is linked with HTRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA2-to-partner and partner-to-HTRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by HTRA2-low versus HTRA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA2→partner) and Y-score (partner→HTRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf52 →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+3.874	<.001	.005	3	1
BLOOD_Leukemia	SMIM31 →	+0.023	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	VSIG10L2 →	+0.132	+3.944	<.001	.006	3	1
LARGE_INTESTINE	MT4 →	+3.892	+3.556	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C5orf52 by HTRA2 expression — BLOOD_Leukemia

Explore this box plot interactively →