HTRA1

Across TCGA patient cohorts, HTRA1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,186 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HTRA1-associated genes across cancer lineages are MYL9, SERPINE1, and COL5A1. Each is linked with HTRA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HTRA1-to-partner and partner-to-HTRA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HTRA1 versus MYL9 in BRCA, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA1→partner) and Y-score (partner→HTRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYL9 →	+1.157	+1.013	<.001	<.001	3	10
OV	SERPINE1 →	+2.185	+1.019	<.001	<.001	3	10
OV	COL5A1 →	+2.262	+1.233	<.001	<.001	3	10
COAD	MSRB3 →	+1.445	+0.996	<.001	<.001	3	10
CCRCC	VGLL3 →	+0.975	+0.698	<.001	<.001	3	10
BRCA	MEIS3 →	+1.164	+0.885	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,186 associations by consensus.

HTRA1 vs MYL9 — BRCA

Explore this scatter interactively →