HTRA1

Across TCGA patient cohorts, HTRA1 mutation is significantly associated with the RNA expression of many other genes, with 1,388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTRA1-associated genes across cancer lineages are TIPIN, RNA5SP321, and EEF1E1-BLOC1S5. Each is linked with HTRA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTRA1-to-partner and partner-to-HTRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPIN grouped by HTRA1-low versus HTRA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA1→partner) and Y-score (partner→HTRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	+0.664	+3.609	<.001	.001	3	3
HNSC	RNA5SP321 →	+0.317	+5.435	<.001	.005	3	2
SKCM	EEF1E1-BLOC1S5 →	+0.027	+2.281	<.001	.006	3	2
SKCM	MIR4482 →	+1.039	+3.093	.006	<.001	3	2
UCEC	PTP4A3 →	-0.960	-3.574	<.001	.002	3	2
UCEC	ATL3 →	+0.611	+2.233	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,388 associations by consensus.

TIPIN by HTRA1 expression — UCEC

Explore this box plot interactively →