HTRA1

Across TCGA patient cohorts, HTRA1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HTRA1-associated genes across cancer lineages are p62 Lck ligand, Stathmin, and GATA3. Each is linked with HTRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA1-to-partner and partner-to-HTRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by HTRA1-low versus HTRA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA1→partner) and Y-score (partner→HTRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p62 Lck ligand →	+0.407	+2.820	.034	.035	3	2
UCEC	Stathmin →	+0.218	+2.115	<.001	.019	3	2
SKCM	GATA3 →	-0.249	-2.321	.009	.035	3	1
SKCM	ACC1 →	+0.379	+2.321	.014	.035	3	1
SKCM	Ku80 →	+0.332	+2.321	.015	.035	3	1
SKCM	N-Cadherin →	-0.201	-2.321	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p62 Lck ligand by HTRA1 expression — SKCM

Explore this box plot interactively →