HTRA1

Across TCGA cell cohorts, HTRA1 mutation is significantly associated with the RNA expression of many other genes, with 584 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTRA1-associated genes across cancer lineages are ZIC5, ABCG4, and PRR23C. Each is linked with HTRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA1-to-partner and partner-to-HTRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by HTRA1-low versus HTRA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA1→partner) and Y-score (partner→HTRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.207	+3.212	<.001	.006	3	2
LARGE_INTESTINE	ABCG4 →	+0.282	+2.674	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
LARGE_INTESTINE	TOMM22 →	+0.607	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CNIH1 →	+0.564	+3.299	.001	.004	3	1
LARGE_INTESTINE	EARS2 →	+0.650	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 584 associations by consensus.

ZIC5 by HTRA1 expression — LARGE_INTESTINE

Explore this box plot interactively →