HTR6

Across TCGA patient cohorts, HTR6 mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR6-associated genes across cancer lineages are RPL17P19, AP1S3, and FBXO22. Each is linked with HTR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR6-to-partner and partner-to-HTR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P19 grouped by HTR6-low versus HTR6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR6→partner) and Y-score (partner→HTR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPL17P19 →	+0.099	+4.548	.005	.001	3	3
UCEC	AP1S3 →	+0.805	+3.483	<.001	.002	3	2
UCEC	FBXO22 →	+0.579	+3.345	<.001	.005	3	2
UCEC	LETM1 →	+0.475	+3.191	.005	.009	3	2
UCEC	POLH →	+0.572	+3.191	.006	.009	3	2
COAD	TRDV3 →	+1.014	+3.178	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

RPL17P19 by HTR6 expression — LUSC

Explore this box plot interactively →