HTR6

Across TCGA patient cohorts, HTR6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR6-associated genes across cancer lineages are G6PD, Heregulin, and MSH2. Each is linked with HTR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR6-to-partner and partner-to-HTR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by HTR6-low versus HTR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR6→partner) and Y-score (partner→HTR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	G6PD →	-0.317	-2.986	.042	.035	3	1
UCEC	Heregulin →	-0.146	-2.986	.014	.035	3	1
UCEC	MSH2 →	-0.345	-2.973	.001	.035	3	1
UCEC	p62 Lck ligand →	+0.539	+2.469	<.001	.010	3	1
UCEC	P-Cadherin →	-0.160	-2.446	.021	.020	3	1
UCEC	Annexin-1 →	+0.572	+2.827	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

G6PD by HTR6 expression — UCEC

Explore this box plot interactively →