HTR4

Across TCGA pan-cancer cohorts, HTR4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HTR4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HTR4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HTR4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, UCEC, and SARC are the cancer types where HTR4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.072	0.798	<.001	32	view →
UCEC	DFS	Median	III,IV	1.000	0.535	.022	16	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LUAD	OS	Median	All	0.338	0.834	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HTR4–LUSC (DFS)

Open the LUSC breakdown →