HTR4

Across TCGA patient cohorts, HTR4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR4-associated genes across cancer lineages are GAPDH, STAT3_pY705, and ASNS. Each is linked with HTR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR4-to-partner and partner-to-HTR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HTR4-low versus HTR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR4→partner) and Y-score (partner→HTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.530	+2.321	.008	.033	3	2
UCEC	STAT3_pY705 →	-0.606	-3.321	<.001	<.001	3	2
UCEC	ASNS →	+0.543	+2.169	<.001	.003	3	2
UCEC	ATM →	-0.692	-3.807	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.110	-1.415	.048	.046	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.765	.023	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by HTR4 expression — UCEC

Explore this box plot interactively →