HTR4

Across TCGA cell cohorts, HTR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 837 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HTR4-associated GO terms across cancer lineages are Cellular response to steroid hormone stimulus, Regulation of MAP kinase activity, and Regulation of PERK-mediated unfolded protein response. Each is linked with HTR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HTR4-to-partner and partner-to-HTR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to steroid hormone stimulus grouped by HTR4-low versus HTR4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR4→partner) and Y-score (partner→HTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cellular response to steroid hormone stimulus →	+0.049	+0.037	.006	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of MAP kinase activity →	+0.073	+0.046	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of PERK-mediated unfolded protein response →	+0.113	+0.047	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of lamellipodium morphogenesis →	+0.086	+0.047	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Cytokinetic process →	+0.080	+0.059	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	Membrane protein proteolysis →	+0.115	+0.049	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 837 associations by consensus.

Cellular response to steroid hormone stimulus by HTR4 expression — OESOPHAGUS

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