Across TCGA pan-cancer cohorts, HTR3E Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HTR3E data layer compared with 20 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTR3E Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HTR3E expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
UCEC, UCS, and LUAD are the cancer types where HTR3E Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.