Across TCGA patient cohorts, HTR3E mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3E-associated genes across cancer lineages are ATM, MEK1, and mTOR_pS2448. Each is linked with HTR3E in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR3E-to-partner and partner-to-HTR3E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3E→partner) and Y-score (partner→HTR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.456	-1.925	.005	.005	3	3
UCEC	MEK1 →	+0.433	+2.502	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.162	-3.886	.002	<.001	3	2
UCEC	PCNA →	+0.175	+1.925	.024	.005	3	2
UCEC	PKC-delta_pS664 →	-0.116	-2.807	.007	.002	3	2
UCEC	Annexin-1 →	+0.404	+1.604	.033	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

HTR3E survival (RNA) · tumor vs normal (RNA) · all HTR3E data types