Across TCGA cell cohorts, HTR3E RNA expression is significantly associated with the go_rna of many other GO terms, with 671 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HTR3E-associated GO terms across cancer lineages are Serotonin-gated cation-selective signaling pathway, Regulation of RIG-I signaling pathway, and Cellular response to exogenous dsRNA. Each is linked with HTR3E in more than 4 cancer types. Because this analysis shows association rather than direction, both HTR3E-to-partner and partner-to-HTR3E results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3E→partner) and Y-score (partner→HTR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Serotonin-gated cation-selective signaling pathway →	+0.462	+0.782	<.001	.001	3	4
CNS	Regulation of RIG-I signaling pathway →	+0.071	+0.030	<.001	.001	2	5
CNS	Cellular response to exogenous dsRNA →	+0.170	+0.023	<.001	<.001	2	5
SOFT_TISSUE	Promoter clearance during DNA-templated transcription →	+0.087	+0.366	<.001	.006	3	3
SOFT_TISSUE	RNA polymerase II promoter clearance →	+0.087	+0.366	<.001	.006	3	3
SOFT_TISSUE	Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress →	+0.310	+0.749	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 671 associations by consensus.

Exploration

HTR3E survival (RNA) · tumor vs normal (RNA) · all HTR3E data types