Across TCGA cell cohorts, HTR3E mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR3E-associated genes across cancer lineages are GP2, FAM205A, and GGTLC2. Each is linked with HTR3E in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3E-to-partner and partner-to-HTR3E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3E→partner) and Y-score (partner→HTR3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GP2 →	+0.635	+3.556	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.023	+3.614	<.001	.006	3	1
SKIN	GGTLC2 →	+0.029	+4.273	.001	.006	3	1
SKIN	ADH4 →	+0.131	+4.095	<.001	.009	3	1
BLOOD_Leukemia	OR1N2 →	+0.033	+3.705	<.001	.007	3	1
BLOOD_Leukemia	AMER3 →	+0.011	+3.944	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

HTR3E survival (RNA) · tumor vs normal (RNA) · all HTR3E data types