HTR3C

Across TCGA patient cohorts, HTR3C mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3C-associated genes across cancer lineages are STAT3_pY705, ATM, and PREX1. Each is linked with HTR3C in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3C-to-partner and partner-to-HTR3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by HTR3C-low versus HTR3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3C→partner) and Y-score (partner→HTR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.358	-2.459	<.001	.018	3	2
UCEC	ATM →	-0.550	-2.169	.001	.003	3	2
SKCM	PREX1 →	-0.489	-2.459	.001	.018	3	1
UCEC	eIF4E →	+0.162	+2.662	.040	<.001	3	1
UCEC	MEK1 →	+0.464	+2.662	<.001	<.001	3	1
UCEC	Notch1 →	+0.178	+2.916	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

STAT3_pY705 by HTR3C expression — UCEC

Explore this box plot interactively →