HTR3C

Across TCGA cell cohorts, HTR3C RNA expression is significantly associated with the go_rna of many other GO terms, with 245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR3C-associated GO terms across cancer lineages are Regulation of sperm capacitation, Microtubule bundle formation, and Response to mitochondrial depolarisation. Each is linked with HTR3C in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR3C-to-partner and partner-to-HTR3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sperm capacitation grouped by HTR3C-low versus HTR3C-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3C→partner) and Y-score (partner→HTR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of sperm capacitation →	+0.424	+0.038	.005	.008	3	4
LARGE_INTESTINE	Microtubule bundle formation →	-0.026	-0.010	<.001	.005	3	3
LARGE_INTESTINE	Response to mitochondrial depolarisation →	+0.062	+0.015	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	Cellular response to heat →	+0.058	+0.011	.004	.008	3	2
CNS	Serotonin-gated cation-selective signaling pathway →	+0.245	+0.039	.003	.007	3	2
LARGE_INTESTINE	Negative regulation of heart rate →	-0.203	-0.010	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

Regulation of sperm capacitation by HTR3C expression — CNS

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