HTR3C

Across TCGA cell cohorts, HTR3C mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible HTR3C-associated genes across cancer lineages are DEFB125, OR10W1, and ETDB. Each is linked with HTR3C in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3C-to-partner and partner-to-HTR3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB125 grouped by HTR3C-low versus HTR3C-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3C→partner) and Y-score (partner→HTR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB125 →	+0.022	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
STOMACH	ETDB →	+0.067	+4.129	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFB125 by HTR3C expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →