HTR3C

Across TCGA cell cohorts, HTR3C mutation is significantly associated with the mutation status of many other genes, with 1,634 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR3C-associated genes across cancer lineages are RPS6KA4, RBMXL3, and MORC3. Each is linked with HTR3C in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR3C-to-partner and partner-to-HTR3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS6KA4 grouped by HTR3C-low versus HTR3C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3C→partner) and Y-score (partner→HTR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPS6KA4 →	+4.000	+5.050	.008	.008	1	4
BREAST	RBMXL3 →	+5.297	+5.297	.004	.004	1	4
BLOOD_Leukemia	MORC3 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	FCRL4 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	JMJD7-PLA2G4B →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	PHF14 →	+4.321	+5.285	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,634 associations by consensus.

RPS6KA4 by HTR3C expression — BLOOD_Leukemia

Explore this box plot interactively →