HTR2B

Across TCGA patient cohorts, HTR2B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR2B-associated genes across cancer lineages are ERK2, Ku80, and MIG-6. Each is linked with HTR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR2B-to-partner and partner-to-HTR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HTR2B-low versus HTR2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2B→partner) and Y-score (partner→HTR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.267	+3.000	.008	.036	3	2
UCEC	Ku80 →	+0.298	+2.183	.016	.035	3	1
UCEC	MIG-6 →	+0.105	+2.183	.043	.035	3	1
UCEC	Smad3 →	+0.175	+3.321	.027	.010	3	1
UCEC	STAT3_pY705 →	-0.482	-3.321	<.001	.010	3	1
UCEC	Bak →	+0.296	+2.999	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ERK2 by HTR2B expression — UCEC

Explore this box plot interactively →