HTR2B

Across TCGA cell cohorts, HTR2B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR2B-associated genes across cancer lineages are LCN1, KCNA4, and ADGRA1. Each is linked with HTR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR2B-to-partner and partner-to-HTR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN1 grouped by HTR2B-low versus HTR2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2B→partner) and Y-score (partner→HTR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCN1 →	+0.057	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.046	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LCN1 by HTR2B expression — BLOOD_Leukemia

Explore this box plot interactively →