HTR2A

Across TCGA pan-cancer cohorts, HTR2A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HTR2A data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTR2A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HTR2A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ESCA, and KIRC are the cancer types where HTR2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.423	.001	36	view →
ESCA	OS	Median	II,III,IV	0.262	0.707	.002	18	view →
KIRC	OS	Median	All	0.152	0.874	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HTR2A–UCEC (DFS)

Open the UCEC breakdown →