HTR2A

Across TCGA cell cohorts, HTR2A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,533 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HTR2A-associated GO terms across cancer lineages are Amyloid-beta clearance by transcytosis, Apoptotic cell clearance, and Golgi vesicle transport. Each is linked with HTR2A in more than 4 cancer types. Because this analysis shows association rather than direction, both HTR2A-to-partner and partner-to-HTR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amyloid-beta clearance by transcytosis grouped by HTR2A-low versus HTR2A-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2A→partner) and Y-score (partner→HTR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Amyloid-beta clearance by transcytosis →	+0.131	+0.914	<.001	<.001	3	5
BONE	Apoptotic cell clearance →	+0.261	+0.713	<.001	.006	3	5
SKIN	Golgi vesicle transport →	+0.047	+0.056	<.001	.002	3	5
BONE	Protein oxidation →	+1.013	+0.472	.001	.008	3	5
BONE	Collagen fibril organization →	+0.297	+0.696	<.001	.004	3	5
BONE	Positive regulation of actin filament bundle assembly →	+0.151	+0.696	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,533 associations by consensus.

Amyloid-beta clearance by transcytosis by HTR2A expression — CNS

Explore this box plot interactively →