HTR2A

Across TCGA cell cohorts, HTR2A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR2A-associated genes across cancer lineages are ZIC3, KRTAP10-1, and NCAN. Each is linked with HTR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR2A-to-partner and partner-to-HTR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC3 grouped by HTR2A-low versus HTR2A-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR2A→partner) and Y-score (partner→HTR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZIC3 →	+0.820	+4.432	.001	.003	3	1
STOMACH	KRTAP10-1 →	+0.031	+4.794	<.001	.001	3	1
LARGE_INTESTINE	NCAN →	+0.195	+3.629	<.001	.003	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TSPY2 →	+0.033	+3.217	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZIC3 by HTR2A expression — STOMACH

Explore this box plot interactively →