HTR1F

Across TCGA pan-cancer cohorts, HTR1F Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated HTR1F data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTR1F Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HTR1F expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and DLBC are the cancer types where HTR1F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.945	0.298	.002	34	view →
HNSC	DFS	Median	III,IV	0.078	0.680	<.001	15	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
BRCA	OS	Median	II,III,IV	0.103	0.565	.001	12	view →
BLCA	OS	Median	III,IV	0.161	0.579	.010	12	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
KIRP	DFS	Median	All	0.133	0.605	.014	6	view →
LIHC	DFS	Median	All	0.283	0.546	.031	6	view →
SKCM	DFS	Median	II,III,IV	0.192	0.590	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

HTR1F–UCEC (DFS)

Open the UCEC breakdown →