HTR1F

Across TCGA cell cohorts, HTR1F mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR1F-associated genes across cancer lineages are FAH, SH3GL2, and ZNF330. Each is linked with HTR1F in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1F-to-partner and partner-to-HTR1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAH grouped by HTR1F-low versus HTR1F-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1F→partner) and Y-score (partner→HTR1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAH →	-0.746	-3.278	.003	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+0.966	+3.667	.006	<.001	3	1
LARGE_INTESTINE	ZNF330 →	+0.536	+3.237	.002	.003	3	1
LARGE_INTESTINE	SLC35D1 →	+0.749	+3.364	.006	.002	3	1
LARGE_INTESTINE	CTH →	+1.219	+3.364	.001	.002	3	1
LARGE_INTESTINE	TNFAIP3 →	-1.195	-3.169	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

FAH by HTR1F expression — LARGE_INTESTINE

Explore this box plot interactively →