HTR1B

Across TCGA pan-cancer cohorts, HTR1B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HTR1B data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HTR1B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where HTR1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.643	0.976	<.001	57	view →
PDAC	DFS	Tertile	All	0.884	0.627	.003	14	view →
CCRCC	OS	Quartile	III,IV	0.982	0.496	.010	9	view →
HNSC	OS	Median	IV	0.725	0.909	.011	8	view →
LSCC	DFS	Quartile	II,III,IV	0.941	0.634	.012	4	view →
GBM	DFS	Median	All	0.655	0.841	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HTR1B–LUAD (OS)

Open the LUAD breakdown →