HTN1

Across TCGA patient cohorts, HTN1 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HTN1-associated genes across cancer lineages are OR7E97P, MIR3144, and MIR1283-1. Each is linked with HTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTN1-to-partner and partner-to-HTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E97P grouped by HTN1-low versus HTN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTN1→partner) and Y-score (partner→HTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E97P →	+0.036	+6.485	<.001	<.001	3	2
LUSC	MIR3144 →	+0.277	+4.906	<.001	.003	3	2
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	2
UCEC	RNA5SP534 →	+0.781	+3.827	<.001	.003	3	1
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
SKCM	OR7A3P →	+0.041	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

OR7E97P by HTN1 expression — SKCM

Explore this box plot interactively →