HTD2

Across TCGA cell cohorts, HTD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,311 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HTD2-associated GO terms across cancer lineages are tRNA 3'-terminal CCA addition, Positive regulation of t-circle formation, and Protein localization to condensed chromosome. Each is linked with HTD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both HTD2-to-partner and partner-to-HTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 3'-terminal CCA addition grouped by HTD2-low versus HTD2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTD2→partner) and Y-score (partner→HTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	tRNA 3'-terminal CCA addition →	+0.153	+0.559	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of t-circle formation →	-0.220	-1.081	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to condensed chromosome →	+0.115	+0.631	<.001	<.001	3	14
BLOOD_Myeloma	Protein import into nucleus →	+0.076	+0.803	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RNA 5'-end processing →	+0.088	+0.747	.002	.003	3	13
BLOOD_Myeloma	Import into nucleus →	+0.066	+0.715	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,311 associations by consensus.

tRNA 3'-terminal CCA addition by HTD2 expression — LIVER

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