HTATSF1

Across TCGA patient cohorts, HTATSF1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTATSF1-associated genes across cancer lineages are 14-3-3_beta, Shc_pY317, and Tuberin. Each is linked with HTATSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTATSF1-to-partner and partner-to-HTATSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HTATSF1-low versus HTATSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTATSF1→partner) and Y-score (partner→HTATSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-2.558	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.097	-1.440	.036	.022	3	2
UCEC	Tuberin →	+0.341	+1.817	<.001	.002	3	2
UCEC	Chk2_pT68 →	-0.132	-1.755	.020	.013	3	2
UCEC	53BP1 →	+0.300	+2.502	.004	.001	3	2
UCEC	eEF2 →	+0.259	+1.700	.018	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

14-3-3_beta by HTATSF1 expression — UCEC

Explore this box plot interactively →