HSPH1

Across TCGA patient cohorts, HSPH1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPH1-associated genes across cancer lineages are ERK2, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with HSPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPH1-to-partner and partner-to-HSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HSPH1-low versus HSPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPH1→partner) and Y-score (partner→HSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.133	+1.432	.019	.005	3	3
UCEC	EGFR_pY1068 →	-0.254	-1.938	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-1.999	<.001	.008	3	2
UCEC	MEK1 →	+0.404	+2.584	<.001	<.001	3	2
UCEC	NDRG1_pT346 →	-0.316	-1.362	.028	.034	3	2
UCEC	TFRC →	+0.605	+2.099	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ERK2 by HSPH1 expression — UCEC

Explore this box plot interactively →