HSPH1

Across TCGA cell cohorts, HSPH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,505 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HSPH1-associated GO terms across cancer lineages are Positive regulation of MHC class I biosynthetic process, Mitotic sister chromatid cohesion, and RNA 5'-end processing. Each is linked with HSPH1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HSPH1-to-partner and partner-to-HSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of MHC class I biosynthetic process grouped by HSPH1-low versus HSPH1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPH1→partner) and Y-score (partner→HSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of MHC class I biosynthetic process →	+0.310	+1.381	<.001	<.001	3	15
OESOPHAGUS	Mitotic sister chromatid cohesion →	+0.171	+1.133	<.001	.001	3	15
BONE	RNA 5'-end processing →	+0.103	+1.270	<.001	<.001	3	15
OESOPHAGUS	Regulation of DNA replication →	+0.075	+0.935	.001	<.001	3	14
BONE	Positive regulation of mitotic sister chromatid separation →	+0.174	+1.082	.005	.003	3	14
OESOPHAGUS	Protein localization to chromosome →	+0.116	+1.163	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

Positive regulation of MHC class I biosynthetic process by HSPH1 expression — URINARY_TRACT

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