HSPG2

Across TCGA patient cohorts, HSPG2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,376 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HSPG2-associated proteins across cancer lineages are TGFB1I1, TIMP2, and VCL_S795. Each is linked with HSPG2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSPG2-to-partner and partner-to-HSPG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPG2 versus TGFB1I1 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPG2→partner) and Y-score (partner→HSPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFB1I1 →	+0.623	+1.309	<.001	<.001	3	8
BRCA	TIMP2 →	+0.641	+0.823	<.001	<.001	3	8
BRCA	VCL_S795 →	+0.676	+1.168	<.001	<.001	3	7
OV	MMP2 →	+0.898	+1.965	<.001	<.001	3	7
OV	OLFML3 →	+0.848	+1.712	<.001	.001	3	7
OV	PCOLCE →	+1.049	+2.099	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,376 associations by consensus.

HSPG2 vs TGFB1I1 — BRCA

Explore this scatter interactively →