HSPG2

Across TCGA patient cohorts, HSPG2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,194 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HSPG2-associated genes across cancer lineages are MYL9, CALD1, and CNN1. Each is linked with HSPG2 in more than 9 cancer types. Because this analysis shows association rather than direction, both HSPG2-to-partner and partner-to-HSPG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPG2 versus MYL9 in COAD, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPG2→partner) and Y-score (partner→HSPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL9 →	+1.201	+0.467	<.001	<.001	3	10
OV	CALD1 →	+1.132	+0.504	<.001	<.001	3	10
UCEC	CNN1 →	+2.009	+0.557	<.001	<.001	3	10
OV	AOC3 →	+1.796	+0.654	<.001	<.001	3	10
OV	TGFB1I1 →	+0.983	+0.465	<.001	<.001	3	10
UCEC	TAGLN →	+2.043	+0.556	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,194 associations by consensus.

HSPG2 vs MYL9 — COAD

Explore this scatter interactively →