HSPG2

Across TCGA patient cohorts, HSPG2 mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPG2-associated genes across cancer lineages are 4E-BP1_pS65, c-Kit, and PKC-b-II_pS660. Each is linked with HSPG2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HSPG2-to-partner and partner-to-HSPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by HSPG2-low versus HSPG2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPG2→partner) and Y-score (partner→HSPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pS65 →	+0.163	+2.807	.004	.003	3	5
COAD	c-Kit →	-0.642	-2.193	<.001	<.001	3	5
COAD	PKC-b-II_pS660 →	-0.270	-1.807	.011	.024	3	4
CESC	ASNS →	+0.381	+2.169	.011	.048	3	4
UCEC	Cyclin-B1 →	+0.551	+1.371	<.001	<.001	3	4
UCEC	MEK1 →	+0.396	+1.491	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

4E-BP1_pS65 by HSPG2 expression — LUAD

Explore this box plot interactively →