HSPE1P28

Across TCGA pan-cancer cohorts, HSPE1P28 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated HSPE1P28 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HSPE1P28 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HSPE1P28 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

SKCM, THCA, and UCEC are the cancer types where HSPE1P28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.550	0.789	<.001	84	view →
THCA	OS	Tertile	II,III,IV	0.250	0.924	<.001	57	view →
UCEC	OS	Tertile	IV	0.349	0.764	.002	54	view →
HNSC	OS	Tertile	III,IV	0.058	0.674	<.001	45	view →
CHOL	DFS	Tertile	All	0.082	0.524	<.001	36	view →
LGG	OS	Tertile	All	0.543	0.815	.001	36	view →
KIRP	OS	Tertile	II,III,IV	0.125	0.715	.003	27	view →
KIRC	DFS	Tertile	III,IV	0.427	0.663	.026	24	view →
COAD	OS	Tertile	IV	0.056	0.659	<.001	18	view →
CESC	DFS	Tertile	IV	0.053	0.529	<.001	18	view →
SARC	DFS	Tertile	All	0.198	0.601	.003	15	view →
PRAD	OS	Tertile	All	0.952	0.996	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

HSPE1P28–SKCM (OS)

Open the SKCM breakdown →