Across TCGA pan-cancer cohorts, HSPD1P9 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HSPD1P9’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where HSPD1P9 RNA is repressed in tumor relative to normal tissue. In most cancer types HSPD1P9 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.
LUSC, PAAD, and BRCA are the cancer types where HSPD1P9 tumor–normal differential expression is most reproducible.