Across TCGA pan-cancer cohorts, HSPD1P8 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HSPD1P8’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where HSPD1P8 RNA is repressed in tumor relative to normal tissue. In most cancer types HSPD1P8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where HSPD1P8 tumor–normal differential expression is most reproducible.