Across TCGA pan-cancer cohorts, HSPD1P16 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HSPD1P16’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where HSPD1P16 RNA is repressed in tumor relative to normal tissue. In most cancer types HSPD1P16 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.
BRCA, KICH, and COAD are the cancer types where HSPD1P16 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPD1P16 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.