HSPD1

Across TCGA pan-cancer cohorts, HSPD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HSPD1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HSPD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HSPD1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and GBM are the cancer types where HSPD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.878	0.613	.014	10	view →
PDAC	OS	Quartile	III,IV	0.202	0.662	.021	6	view →
GBM	OS	Quartile	All	0.878	0.771	.021	4	view →
LUAD	DFS	Quartile	III,IV	0.993	0.464	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HSPD1–LSCC (OS)

Open the LSCC breakdown →