HSPD1

Across TCGA patient cohorts, HSPD1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,952 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSPD1-associated genes across cancer lineages are SYNE1, ZCCHC24, and LRRK2. Each is linked with HSPD1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSPD1-to-partner and partner-to-HSPD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPD1 versus SYNE1 in UCEC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPD1→partner) and Y-score (partner→HSPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNE1 →	-0.861	-0.350	<.001	.002	3	8
OV	ZCCHC24 →	-1.356	-0.592	<.001	<.001	3	8
LSCC	LRRK2 →	-1.327	-0.395	<.001	<.001	3	8
OV	IFFO1 →	-1.223	-0.585	<.001	<.001	3	7
OV	CD33 →	-0.696	-0.612	<.001	<.001	3	7
OV	PMP22 →	-1.180	-0.714	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,952 associations by consensus.

HSPD1 vs SYNE1 — UCEC

Explore this scatter interactively →